58. Chan EY, Kir S, Tooze SA. siRNA screening of the kinome identifies ULK1 as a multidomain modulator of autophagy. J Biol Chem. 2007; 282:25464–25474. [PubMed: 17595159]

59. LiangXH, Jackson S, Seaman M, Brown K, Kempkes B, Hibshoosh H, et al. Induction of

autophagy and inhibition of tumorigenesis by beclin 1. Nature. 1999; 402:672–676. [PubMed: 10604474]

60. Ichimura Y, Kirisako T, Takao T, Satomi Y, Shimonishi Y, Ishihara N, et al. A ubiquitin-like system mediates protein lipidation. Nature. 2000; 408:488–492. [PubMed: 11100732]

61. Mizushima N, Kuma A, Kobayashi Y, Yamamoto A, Matsubae M, Takao T, et al. Mouse Apg16L, a novel WD-repeat protein, targets to the autophagic isolation membrane with the Apg12-Apg5 conjugate. J Cell Sci. 2003; 116:1679–1688. [PubMed: 12665549]

62. Mizushima N, Yoshimori T, Ohsumi Y. The role of Atg proteins in autophagosome formation. Annu Rev Cell Dev Biol. 2011; 27:107–132. [PubMed: 21801009]

63. Klionsky DJ, Schulman BA. Dynamic regulation of macroautophagy by distinctive ubiquitin-like proteins. Nat Struct Mol Biol. 2014; 21:336–345. [PubMed: 24699082]