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Product Details

About InVivoPlus anti-mouse PD-L1 (B7-H1)

The 10F.9G2 monoclonal antibody reacts with mouse PD-L1 (programmed death ligａnd 1) also known as B7-H1 or CD274. PD-L1 is a 40 kDa type I transmembrane protein that belongs to the B7 family of the Ig superfamily. PD-L1 is expressed on T lymphocytes, B lymphocytes, NK cells, dendritic cells, as well as IFNγ stimulated monocytes, epithelial cells and endothelial cells. PD-L1 binds to its receptor, PD-1, found on CD4 and CD8 thymocytes as well as activated T and B lymphocytes and myeloid cells. Engagement of PD-L1 with PD-1 leads to inhibition of TCR-mediated T cell proliferation and cytokine production. PD-L1 is thought to play an important role in tumor immune evasion. Induced PD-L1 expression is common in many tumors and results in increased resistance of tumor cells to CD8 T cell mediated lysis. In mouse models of melanoma, tumor growth can be transiently arrested via treatment with antibodies which block the interaction between PD-L1 and PD-1. The 10F.9G2 antibody has been shown to block the interaction between PD-L1 and PD-1 and between PD-L1 and B7-1 (CD80).

InVivoPlus anti-mouse PD-L1 (B7-H1) Specifications

Production	Purified from tissue culture supernatant in an animal free facility
Purification	Protein G
RRID	AB_10949073
Molecular Weight	150 kDa
*Murine Pathogen Test Results	Mouse Norovirus: Negative
	Mouse Parvovirus: Negative
	Mouse Minute Virus: Negative
	Mouse Hepatitis Virus: Negative
	Reovirus Screen: Negative
	Lymphocytic Choriomeningitis virus: Negative
	Lactate Dehydrogenase-Elevating Virus: Negative
	Mouse Rotavirus: Negative
	Theiler’s Murine Encephalomyelitis: Negative
	Ectromelia/Mousepox Virus: Negative
	Hantavirus: Negative
	Polyoma Virus: Negative
	Mouse Adenovirus: Negative
	Sendai Virus: Negative
	Mycoplasma Pulmonis: Negative
	Pneumonia Virus of Mice: Negative
	Mouse Cytomegalovirus: Negative
	K Virus: Negative
Storage	The antibody solution should be stored at the stock concentration at 4°C. Do not freeze.

* Additional quality control measures for our InVivoPlus™ products include advanced binding validation, murine pathogen screening, protein aggregation screening, and ultra-low endotoxin levels. The superior quality of our InVivoPlus™ products will meet and exceed the strict demands and rigorous standards required for in vivo research.