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產品英文名稱 | Human RSPO1/R-spondin-1 Protein |
產品中文名稱 | 重組人RSPO1/R-spondin-1 蛋白(RSPO1/R-spondin-1) |
別名 | RSPO1, Roof plate-specific spondin-1 |
標簽 | 無標簽 |
表達宿主 | 大腸桿菌 |
種屬 | 人 |
序列 | 氨基酸序列來源于:人源RSPO1 (Q2MKA7) (Ser21-Ala263) 表達的蛋白片段。 |
活性 | Testing in Progress |
蛋白長度 | 重組人RSPO1 由243個氨基酸組成,預測分子量為26.7 KD。 |
純度 | > 98 % ,使用SDS-PAGE檢測 |
特點&優勢 | 通過LAL法測定,每微克蛋白里內毒素含量<0.1>0.1> |
產品形式 | 凍干粉,凍干緩沖液為無菌的20 mM Tris,50 mM NaCl,pH 8.0。 |
基因ID | 192199 |
蛋白序列鏈接 | RSPO1 - R-spondin-1 - Homo sapiens (Human) | UniProtKB | UniProt |
使用中注意事項 | 開蓋使用前,請先離心。本產品為凍干粉,推薦用該產品配套的Reconstitution Buffer進行復溶,且濃度不低于108 µg/mL。客戶可根據后續的實驗需求,進行進一步的稀釋。 |
保存建議 | 本產品為凍干粉形式,建議:將凍干粉產品保存于-20℃以下的干燥環境中。本產品溶解之后,可在4℃保存2-7天,長期使用請置于-20℃以下。為長期保存,推薦添加載體蛋白(0.1% HSA或者BSA),并酌情分裝保存,避免反復凍融。 |
運輸條件 | 冰袋運輸(藍冰) |
警告 | 本文列出的產品僅供研究使用,不適用于人類或臨床診斷。我們產品所推薦應用,不是建議使用我們的產品去違反任何或許可證。對于使用本產品可能發生的侵權或其他違規行為,我們不承擔任何責任。 |
背景 | RSPO1 is a secreted protein,containing 2 FU (furin-like) repeats and 1 TSP type-1 domain and belonging to the R-spondin family. RSPO1 is required for the early development of gonads, regardless of sex. It has been found in mice only eleven days after fertilization. To induce cell proliferation, it acts synergistically with WNT4. They help stabilize β catenin, which activates downstream targets. RSPO1 is necessary in female sex development. It augments the WNT/β catenin pathway to oppose male sex development. In critical gonadal stages, between six and nine weeks after fertilization, the ovaries upregulate it while the testes downregulate it. RSPO1 can potentially aid in the treatment of mucositis, which is characterized by inflammation of the oral cavity. This unfortunate condition often accompanies chemotherapy and radiation in cancer patients with head and neck tumors. |
Fig.Human RSPO1 Protein