成人做爰免费视频免费看_成人a级高清视频在线观看,成人a大片在线观看,成人a大片高清在线观看,成人av在线播放,一a一级片,一级黄 中国色 片,一级黄 色蝶 片,一级黄色 片生活片

武漢原生原代生物醫(yī)藥科技有限公司

賀中國(guó)科學(xué)院工程研究所和清華大學(xué)生命科學(xué)學(xué)院應(yīng)用PriCe

時(shí)間:2021-09-06
分享:

  
賀中國(guó)科學(xué)院工程研究所和清華大學(xué)生命科學(xué)學(xué)院應(yīng)用PriCells產(chǎn)品/技術(shù)服務(wù)發(fā)表文章
 
Activated Scavenger Receptor A Promotes Glial Internalization of Ab
 
PLOS ONE Published: April 09,2014 DOI:10.1371/journal.pone.0094197
 
He Zhang1,2, Ya-jing Su3, Wei-wei Zhou1, Shao-wei Wang1, Peng-xin Xu1, Xiao-lin Yu1*, Rui-tian Liu1*
 
National Key Laboratory of Biochemical Engineering, Institute of Process Engineering, Chinese Academy of Sciences, Beijing, China,
Tsinghua University School of Medicine, Haidian District, Beijing, China, 
3 School of Life Science, Ningxia University, Yinchuan, China
 
Abstract
Beta-amyloid (Aβ) aggregates have a pivotal role in pathological processing of Alzheimer’s disease (AD). The clearance of Aβ monomer or aggregates is a causal strategy for AD treatment. Microglia and astrocytes are the main macrophages that exert critical neuroprotective roles in the brain. They may effectively clear the toxic accumulation of Aβ at the initial stage of AD, however, their functions are attenuated because of glial overactivation. In this study, we first showed that heptapeptide XD4 activates the class A scavenger receptor (SR-A) on the glia by increasing the binding of Aβ to SR-A, thereby promoting glial phagocytosis of Aβ oligomer in microglia and astrocytes and triggering intracellular mitogen-activated protein kinase (MAPK) signaling cascades. Moreover, XD4 enhances the internalization of Aβ monomers to microglia and astrocytes through macropinocytosis or SR-A-mediated phagocytosis. Furthermore, XD4 significantly inhibits Aβ oligomer-induced cytotoxicity to glial cells and decreases the production of proinflammatory cytokines, such as TNF-α and IL-1β, in vitro and in vivo. Our findings may provide a novel strategy for AD treatment by activating SR-A.
 
MIC-CELL-0077 / MED-0014,PriCells



會(huì)員登錄

×

請(qǐng)輸入賬號(hào)

請(qǐng)輸入密碼

=

請(qǐng)輸驗(yàn)證碼

收藏該商鋪

X
該信息已收藏!
標(biāo)簽:
保存成功

(空格分隔,最多3個(gè),單個(gè)標(biāo)簽最多10個(gè)字符)

常用:

提示

X
您的留言已提交成功!我們將在第一時(shí)間回復(fù)您~
撥打電話 產(chǎn)品分類
在線留言
主站蜘蛛池模板: 午夜精品射精入后重之免费观看| 欧美日韩亚洲性| 国产日韩 在线| 一区二区三区国产| 亚洲字幕成人中文在线电影网| 国产SM调教折磨视频| 亚洲不卡中文字幕无码| 国产成人精品三级在线| 欧美精品久久久久久a| 国产精品亚洲精品久久品| 老色69久久九九精品高潮| 国产日韩欧美高清一区| 欧美精品99久久久久久| 性一交一乱一伧一小说有声| 日韩欧美大片免费| 兰桂坊人成社区亚洲精品| 精品夜夜爽欧美毛片视频| 亚洲精品成人影院| 久久久久久久久久久午夜| 欧美日韩理论片| 国产最新三级强a乱在线看| 日韩人妻中文在线| 欧美日精品在线| 伦理片在线观看午夜伦理电影韩国| 长篇YIN荡乱合集小说免费TXT下载| 麻豆国产人妻精品无码AV| 在教室伦流澡到高潮H吃奶小黄书| 麻豆爽爽妓女一区二区三区| 欧美亚洲久久久| 好大好硬好爽好深好硬视频| 国产又粗又长又硬又猛A片| 欧美国产一区二区三区激情无套| 国产欧美在线观看91性色| 国产欧美日韩精品久久久| 精品人妻无码日本一区二区三区| 欧美日韩在线永久| 久久99九九国产免费看小说| 国产性夜夜春夜夜爽1A片| 欧美性色综合网| 精品欧美日韩国产| 精品性高朝久久久久久久|