成人做爰免费视频免费看_成人a级高清视频在线观看,成人a大片在线观看,成人a大片高清在线观看,成人av在线播放,一a一级片,一级黄 中国色 片,一级黄 色蝶 片,一级黄色 片生活片

武漢艾美捷科技有限公司
初級會員 | 第6年

13797054889

多功能艾美捷鈣網蛋白(CRT)單克隆抗體

時間:2023/2/8閱讀:212
分享:

The multifunctional, multi -compartmental protein Calreticulin (Crt) functions as a soluble molecular chaperone of new or misfolded proteins, as well as a Ca2+-binding protein. Most abundant in the ER lumen, Crt expression also occurs in other membrane-bound organelles, the cell surface, and extracellularly. Also known as CRP-55, calregulin and HACBP (high affinity calcium-binding protein), Crt contains the ER-retrieval sequence, KDEL, and is the solub le paralog of the ER membrane protein Calnexin (Cnx). Crt's three domains include a 180 residue N-terminal domain, a proline-rich Pdomainresidues 189 -288) that binds Ca2+ with high affinity and shares homology with Cnx and calmegin, and a 110 residue C-terminal domain that binds Ca2+ with low affinity but high capacity. The P-domain may interact with the co-chaperone ERp57 (Grp58), a thiol reductase. The NMR structure of the P -domain consists of an extended hairpin that appears to form a curved protrusion from the Crt core domain. Both Crt and its membrane bound homolog CNX interact with proteins and glycoproteins possessing monoglucosylated N -glycans. The Crt/Cnx cycle promotes correct folding, inhibits aggregation of folding intermediates, blocks premature oligomerization, regulates ER degradation, and prevents incompletely folded glycoproteins from exiting to the Golgi complex. Crt also appears to function as an auto-antigen in systemic lupus erythematosus, rheumatoid arthritis, celiac disease, complete congenital heart block, and halothane hepatitis. A diversity of additional functions attributed to Crt includes adhesion, blood function, and cardiac and neuronal development gene expression.

 

多功能、多區室蛋白鈣網蛋白(Crt)可作為新的或錯誤折疊的蛋白質的可溶性分子伴侶,以及Ca2+結合蛋白。Crt 表達在 ER 管腔中最為豐富,也發生在其他膜結合細胞器、細胞表面和細胞外。Crt 也稱為 CRP-55、鈣調節蛋白和 HACBP(高親和力鈣結合蛋白),含有 ER 檢索序列 KDEL,是 ER 膜蛋白鈣連接蛋白 (Cnx) 的可溶物。

 

CRT 似乎也可作為系統性紅斑狼瘡、類風濕性關節炎、乳糜瀉、完-全性先天性心臟傳導阻滯和氟烷肝炎的自身抗原發揮作用。Crt 的多種附加功能包括粘附、血液功能以及心臟和神經元發育基因表達。

638114706279652253946.jpg

艾美捷鈣網蛋白(CRT)單克隆抗體(ADI-SPA-601PE-D)基本參數:

克隆: FMC 75

宿主: 

同種型: 免疫球蛋白G1

免疫原: 重組鈣網蛋白。

源: 從腹水中凈化

物種反應性: 人類

猴子

應用: 流式細胞術

推薦稀釋度/條件: 流式細胞術 (1:100)

建議的稀釋度/條件可能不適用于所有應用。

應用說明: 預測分子量為~63kDa。

純度細節: 蛋白G親和純化。

配方: 液。在PBS中,pH 7.2,含有0.09%疊丨氮丨化鈉。

處理: 避免凍融循環。避光。

航運: 藍冰不結冰

長期儲存: +4°C

 

鈣網蛋白(CRT)單克隆抗體部分文獻引用:

CD47 Blockade Leads to Chemokine-Dependent Monocyte Infiltration and Loss of B Cells from the Splenic Marginal Zone: Y. Y. Yiu, et al.; J. Immunol. 208, 1371 (2022);

IMMUNEPOTENT CRP induces DAMPS release and ROS-dependent autophagosome formation in HeLa and MCF-7 cells: A.C. Martinez-Torres, et al.; BMC Cancer 20, 647 (2020); Full Text

Programmed cell removal by calreticulin in tissue homeostasis and cancer: M. Feng, et al.; Nat. Commun. 9, 3194 (2018);

CD47 Blockade Leads to Chemokine-Dependent Monocyte Infiltration and Loss of B Cells from the Splenic Marginal Zone: Y. Y. Yiu, et al.; J. Immunol. 208, 1371 (2022);

IMMUNEPOTENT CRP induces DAMPS release and ROS-dependent autophagosome formation in HeLa and MCF-7 cells: A.C. Martinez-Torres, et al.; BMC Cancer 20, 647 (2020); Full Text

Programmed cell removal by calreticulin in tissue homeostasis and cancer: M. Feng, et al.; Nat. Commun. 9, 3194 (2018);

 

鈣網蛋白(CRT)單克隆抗體相關研究:

鈣網蛋白單克隆抗體 (FMC 75)ADI-SPA-601-F

鈣網蛋白單克隆抗體 (FMC 75)(DyLight™ 488 偶聯物) ADI-SPA-601-488-F

小鼠 IgG1 同種型對照,單克隆抗體 (MOPC-21)(PE 偶聯物) ADI-SAB-600PE-F


會員登錄

×

請輸入賬號

請輸入密碼

=

請輸驗證碼

收藏該商鋪

X
該信息已收藏!
標簽:
保存成功

(空格分隔,最多3個,單個標簽最多10個字符)

常用:

提示

X
您的留言已提交成功!我們將在第一時間回復您~
撥打電話
在線留言
主站蜘蛛池模板: 三级黄色毛片网站| A片太大太长太深好爽A片视频| 久久久精品欧美一区二区免费| 国产人妻精品无码一区街头街头| 麻豆传煤传媒网址| 亚洲天堂av一区二区三区| 人妻一区中文字幕| 欧美又粗又大又黄A片| 狠狠躁日日躁夜夜躁A片小说| 欧美日韩亚洲国产成人| 久久精品少妇高潮A片免费观| 欧美又黑又大AAA毛片| 中文日韩欧美一区二区三区| 在线免费观看毛片网站| 欧美日韩国产精品伦一区二区| 日本人大战黑人无码| 一区二区三区国产| 偷偷鲁手机在线播放AV| 国产最新AV在线播放不卡| 中文字幕みすのあおい| 国产一区二区三区四区五在线观看| 久久婷婷五月综合色精品首页| 国产真人性做爰久久网站| 艳妇乳肉豪妇荡乳a亚洲| 日产日韩亚洲欧美综合搜索| 日韩小视频中文字幕| 久久久久久久久久久熟女av| 国产AVXXXX无套内射| 成人大香蕉av| 久久久久久久国产精品电影| 神马影院电影888午夜理论不卡| 国产91久久久久久| 韩国少妇激三级做爰在线观看| 日韩一级片内射视频群批| 人人做天天爱夜夜爽2020| 国产精品久久久久久久久99热| 国产精品熟女久久久久久| 男人女人黄 色视频| 亚洲中文精品久久久久久| 亚洲精品中文字幕制| 中文字幕婷婷|日韩|