環(huán)巴胺(Cyclopamine)從藜蘆屬植物內(nèi)分離得到的一種異甾體類生物堿，主要存在百合科植物中北美山藜蘆(Veratrum californicum)、印第安鹿食草(Corn lily)及毛葉藜蘆(Veratrum grandiflorum)、伊貝(Fritillaria pallidiflora Schrenk)四種植物。

環(huán)巴胺對Hedgehog信號通路有抑制作用,在抗腫瘤方面表現(xiàn)出良好的活性。研究表明，環(huán)巴胺可以對Hedgehog信號通路的激活起到抑制作用，而后者參與原癌基因 Smoothened (Smo) 或滅活腫瘤抑制基因 Patched (Ptch) 的突變相關(guān)反應(yīng)途徑，并且這兩種基因都能夠編碼多程跨膜蛋白。此外，已經(jīng)證明環(huán)巴胺的抑制作用是由于其與Smo七螺旋蛋白束的直接結(jié)合有關(guān)。

艾美捷丨LC Laboratories 環(huán)巴胺 / Cyclopamine 目前已經(jīng)應(yīng)用到quan球4100個實驗室，純度非常高，當(dāng)然價格也是十分友好的。

環(huán)巴胺 / Cyclopamine 其它基本參數(shù)：

cat# LCL-C-8700

規(guī)格 10mg/25mg/100mg/300mg

CAS號 4449-51-8

分子式 C27H41NO2

分子量 411.62

純度 ＞99%

外觀 白色結(jié)晶固體；或小瓶底部透明固體膜

溶解性 溶于乙醇或DMSO

運輸與保存方法 常溫運輸；-20℃保存

Nature communications正文引用：

其他參考文獻

[1]. Peukert S, et al. Identification and structure-activity relationships of ortho-biphenyl carboxamides as potent Smoothened antagonists inhibiting the Hedgehog signaling pathway. Bioorg Med Chem Lett, 2009, 19(2), 328-331.

[2]. Berman DM, et al. Widespread requirement for Hedgehog ligand stimulation in growth of digestive tract tumours. Nature, 2003, 425(6960), 846-851.

[3]. Thayer SP, et al. Hedgehog is an early and late mediator of pancreatic cancer tumorigenesis. Nature, 2003, 425(6960), 851-856.

[4]. Ma W, et al. Reduced Smoothened level rescued Aβ-induced memory deficits and neuronal inflammation in animal models of Alzheimer's disease. J Genet Genomics. 2018 May 20;45(5):237-246.

[5]. Qi Wan, et al. Overexpression of Laminin α4 Facilitates Proliferation and Migration of Fibroblasts in Knee Arthrofibrosis by Targeting Canonical Shh/Gli1 Signaling. Connect Tissue Res. 2020 May 24.