成人做爰免费视频免费看_成人a级高清视频在线观看,成人a大片在线观看,成人a大片高清在线观看,成人av在线播放,一a一级片,一级黄 中国色 片,一级黄 色蝶 片,一级黄色 片生活片

產品展廳收藏該商鋪

您好 登錄 注冊

當前位置:
蘇州螞蟻淘生物科技有限公司>供求商機>Chromotek/F2H®-Kit Androgen Receptor
Chromotek/F2H®-Kit Androgen Receptor
返回列表頁
  • Chromotek/F2H®-Kit Androgen Receptor

舉報
貨物所在地: 江蘇蘇州市
地: 美國
更新時間: 2025-01-22 21:00:06
期: 2025年1月22日--2025年7月22日
已獲點擊: 824
在線詢價收藏產品

(聯系我們,請說明是在 化工儀器網 上看到的信息,謝謝!)

產品簡介

Chromotek/F2H®-Kit Androgen Receptor Analyze modulators of the human Androgen Receptor
  Detect early steps of Androgen Receptor activation

詳細介紹

Chromotek/F2H®-Kit Androgen Receptor

 螞蟻淘介紹:

螞蟻淘,【*極速】生物醫學科研用品輕松購

螞蟻淘(ebiomall)是一家生命科學領域的垂直電商平臺,公司專注生物醫學科研用品的  導購和品牌推廣,為海外廠方與國內代理經銷商搭建跨境貿易系統和交流平臺。

    產品齊全,200+分類,1000+品牌,500+產品信息。**,專業售后,到貨快,在線下單, 簡單輕松,節省科學家寶貴的科研時間。

借助互聯網平等而開放的力量,矢志實現生命科學領域的信息同步,我們相信一群充滿夢想的人,可以憑借著專業與執著,讓你的購物更輕松!

Chromotek/F2H®-Kit Androgen Receptor

  Analyze modulators of the human Androgen Receptor

  Detect early steps of Androgen Receptor activation

  Visualized in live mammalian cells

  Real-time agonists and antagonists screening

  Convenient readout using an epi-fluorescence microscope

  The human Androgen receptor (AR) is an important target for developing drug therapies combating prostate cancer. The very early event in AR activation, namely the intramolecular interaction between the N- and C-terminus of AR, can now be analyzed with the ChromoTek Fluorescent-Two Hybrid (F2H®) AR: wild-type (wt), as well as several mutant AR forms can be investigated.

Chromotek/F2H®-Kit Androgen Receptor  

Assay principle:

  AR is expressed as two separate domains: AR-LBD (ligand binding domain), comprising the AR’s C-terminus, either wt or mut, fused to GFP: AR-LBD-GFP

  AR-NTD (N-terminal domain), comprising the AR’s N-terminus, fused to RFP: AR-NTD-RFP

  F2H®-BHK cells express components of the protein-protein interaction platform, which recruits GFP-tagged AR-LBD to a specific location in the nucleus

  AR-LBD-GFP and AR-NTD-RFP constructs are co-transfected into the F2H®-BHK cells

  AR-LBD-GFP forms a bright green spot at the specific location in the nuclei whereas AR-NTD-RFP is diffusely distributed in the nucleus

  Upon stimulation by an agonist (e.g. DHT), immobilized AR-LBD-GFP undergoes a conformation change and recruits AR-NTD-RFP: AR-NTD-RFP forms a bright red spot superimposed with the green spot.

  Results:

  Green spot is present, red spot is absent => assay works: no interaction

  Green spot is present, red spot is present at the same location => assay works: interaction

  

 

  Figure: AR-LBD-GFP (top left) forms bright green spots at the genetic Platform in nuclei of F2H-BHK cells. Before addition of DHT, AR-NTD-RFP (bottom left) is dispersed in the nuclei. Upon 20 min incubation with 10nM DHT, the red spots appear (bottom right, arrows) at the location of the green spots, indicating induction of the interaction between AR-LBD and AR-NTD.

  Reversible Screening:

  The F2H AR assay is fully reversible: the AR wt interaction can be induced by an agonist (e.g. 0.25nM DHT) and then subsequently disrupted by addition of a potent antagonist (e.g. 10µM bicalutamide).

收藏該商鋪

登錄 后再收藏

提示

您的留言已提交成功!我們將在第一時間回復您~

對比框

產品對比 產品對比 聯系電話 二維碼 意見反饋 在線交流

掃一掃訪問手機商鋪
18915418616
在線留言
主站蜘蛛池模板: 免费观看又色又爽又黄的| 快穿被各种男主强好爽H| 6080YYY午夜理论片在线观看| 免费看的久久久久| 亚洲国产精品久久久久久久| 大陆一级毛片免费高清| 一女多男两根同时进去TXT| 山寨版黄蓉色情史| 欧美激情亚洲一区二区三区| 亚洲精品成人区在线观看| 日韩在线中文字幕在线观看| 日本三级香港三级人妇99| 日本精品一区二区三区在线| 日本亚欧色情| 日韩一卡二卡三卡四卡免费观在线| 久久天天婷婷五月俺也去| 亚洲精品久久久久无码AV| 中文字幕小少妇| 国产色情无码网站视频APP| 亚洲欧美日韩一区二区在线| 偷拍亚洲制服另类无码专区| 亚洲AV国产精品无码A片APP| 欧美亚洲精品自拍| 精品人妻无码一区二区三区网站| 国产婷婷午夜精品无码A片| 欧美激情 亚洲 在线| 国精一区二区AV在线观看网站| 我和亲女乱小说录目伦| 永久免费的污视频网站| 亚洲精品天堂中文字幕影院| 啊啊啊国产视频| 久久精品国产亚洲av热九| 国产 精品 麻豆| 邪恶肉肉全彩色无遮盖无翼海贼王| 国产AV国片偷人妻麻豆潘甜软件| 91av影院| 在镜子面前做开车疼小说片段| 欧美日韩国产另类一区二区| 男女生爽爽爽视频免费观看| 男人天堂av伊人| 老司机在线精品视频网站|