成人做爰免费视频免费看_成人a级高清视频在线观看,成人a大片在线观看,成人a大片高清在线观看,成人av在线播放,一a一级片,一级黄 中国色 片,一级黄 色蝶 片,一级黄色 片生活片

產(chǎn)品名稱：Paclitaxel

化學(xué)名：N-BENZYL-BETA-PHENYLISOSERINE ESTER

CAS No： 33069-62-4

分子式：C47H51NO14

分子量：853.92

純度：99%

溶解度：Soluble to 25 mM in ethanol and to 100 mM in DMSO with gentle warming

保存：2-8°C

--------------------------------------------------------------------------------------------------------

貨號：abs810020

規(guī)格： 大包裝詢價

庫存：現(xiàn)貨

-----------------------------------------------------------------------------------------------------------

生物活性：

Antitumor agent; promotes and stabilizes tubulin polymerization, causing cell cycle arrest. Induces autocatalytic activation of caspase-10 in CCRF-HSB-2cells, triggering apoptosis.

It selectively inhibits the proliferation of human endothelial cells (ECs) at ultra low concentrations (0.1-100 pM), while it inhibits non-endothelial type human cells at 10(4) - to 10(5) -fold higher concentrations, with IC50 = 1-10 nM. The selectivity of paclitaxel inhibition of cell proliferation is also species specific, as mouse ECs are not sensitive to paclitaxel at ultra low concentrations. They are inhibited by higher concentrations of paclitaxel with IC50 = 1-10 nM. Inhibition of human ECs by paclitaxel at ultra low concentrations does not affect the cellular microtubule structure. Paclitaxel blocks cells in G2-M, and this may result in a schedule-dependent effect on paclitaxel cytotoxicity.

----------------------------------------------------------------------------------------------------------------------------------------------

參考文獻(xiàn):

1.Tubulin as a target for anticancer drugs: agents which interact with the mitotic spindle. Jordan, A., et al.

Med. Res. Rev. 18, 259-296, (1998)

2.Targeting microtubules for cancer chemotherapy Zhou J, and Giannakakou P. Curr. Med. Chem.

Anticancer Agents 5, 65-71, (2005)

3.Microtubule-stabilizing natural products as promising cancer therapeutics Gallagher BM Jr. Curr. Med.

Chem. 14, 2959-2967, (2007)

4.Taxanes, microtubules and chemoresistant breast cancer McGrogan BT, et al. Biochim. Biophys. Acta

1785, 96-132, (2008)

5.Extensive Crosstalk Between O-GlcNAcylation And Phosphorylation Regulates Cytokinesis. Wang, Z.,

et al. Sci. Signal. 3, ra2, (2010)

-------------------------------------------------------------------------------------------------------------------------

Research Use only 試驗室研究用