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[供應(yīng)]06111-50-Anti-Human CD4 FITC
Human peripheral blood lymphocytes were stained with FITC OKT4 with relevant isotype control in Red.
The OKT4 monoclonal antibody specifically binds to the CD4 receptor for the human immunodeficiency virus (HIV). CD4 is a 59 kDa single-chain transmembrane glycoprotein that expressed on the surface of most of the thymocytes, T-helper cells, and in low levels on monocytes and macrophages. CD4 is a co-receptor in the antigen-induced T cell activation (together with the MHC class II). The OKT4 and the RPA-T4 monoclonal antibodies recognize different epitopes of CD4 and they do not exhibit cross-block binding.
OKT4單克隆抗體特異性結(jié)合CD4受體為人類免疫缺陷病毒（HIV）。 CD4是一個59 kDa的單鏈跨膜糖蛋白，其表達(dá)的大多數(shù)的胸腺細(xì)胞，T輔助細(xì)胞的表面上，并在低的水平上的單核細(xì)胞和巨噬細(xì)胞。 CD4是一個共受體在抗原誘導(dǎo)的T細(xì)胞活化（第II類MHC在一起）。的OKT4和RPA-T4的單克隆抗體識別的CD4的不同表位和它們不表現(xiàn)出交叉阻斷結(jié)合。
Clone | OKT4 |
Format: | FITC |
Applications | FC |
Reactivity | Human |
Isotype: | Mouse IgG2b, kappa |
| Research Interest: | Adaptive Immunity |
| Cell Type: | Monocytes and Macrophages, T Cells, Treg cells, Th17 cells |
Preperation: | The product should be stored undiluted at 4°C and should be protected from prolonged exposure to light. Do not freeze. The monoclonal antibody was purified utilizing affinity chromatography and unreacted dye was removed from the product. |
Formulation: | Phosphate-buffered aqueous solution, ≤0.09% Sodium azide, may contain carrier protein/stabilizer, ph7.2. |
References: | Reinherz, E. L., Kung, P. C., Goldstein, G., & Schlossman, S. F. (1979). Separation of functional subsets of human T cells by a monoclonal antibody.Proceedings of the National Academy of Sciences, 76(8), 4061-4065. Knapp W (1989) Leucocyte typing IV: white cell differentiation antigens. Oxford University Press, 1989. Bour, S. T. E. P. H. A. N. E., Boulerice, F. R. A. N. C. O. I. S., & Wainberg, M. A. (1991). Inhibition of gp160 and CD4 maturation in U937 cells after both defective and productive infections by human immunodeficiency virus type 1.Journal of virology, 65(12), 6387-6396. |
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