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BioXcell：InVivoMAb anti-mouse CSF1R (CD115)

閱讀：642 發布時間：2022-8-1

一、產品介紹
落刺激因子1受體(CSF1R)，也稱為巨噬細胞集落刺激因子受體(M-CSFR)，即CD115反應。CSF1R是一種單程I型膜蛋白，是血小板衍生生長因子受體家族的成員。在小鼠中，CSF1R由單核細胞/巨噬細胞、腹膜滲出物細胞、漿細胞樣和常規樹突細胞以及破骨細胞表達。CSF1R是CSF1的受體，CSF1R通過CSF1R調節單核細胞譜系中細胞的增殖和分化。據報道，克隆號AFS98抗體可在體內deplete巨噬細胞并阻斷CSFR1。

二、產品詳情

產品詳情
產品貨號	BE0213
產品規格	1/5/25/50/100mg
抗體亞型	Rat IgG2a, κ
推薦同型對照	InVivoMAb rat IgG2a isotype control, anti-trinitrophenol（貨號：BE0089）
推薦抗體稀釋液	InVivoPure™ pH 7.0 Dilution Buffer（貨號：IP0070）
免疫原	Not available or unknown
應用	in vivo macrophage depletion/in vitro CSF1R neutralization/in vivo monocyte depletion/Flow cytometry/Western blot
產品形式	PBS , pH 7.0 Contains no stabilizers or preservatives
內毒素水平	<2EU/mg (<0.002EU/μg) 使用 LAL gel clotting 測定
純度	>95% Determined by SDS-PAGE
無菌處理	0.2 μM filtered
生產形式	從組織培養上清液中純化得到。
純化形式	Protein G
RRID	AB_2687699
分子量大小	150 kDa
保存條件	抗體原溶液應保存在4°C條件下，不要冷凍保存。

三、已發表文獻

用途	已發表文獻
in vivo macrophage depletion	Bauche, D., et al. (2018). “LAG3(+) Regulatory T Cells Restrain Interleukin-23-Producing CX3CR1(+) Gut-Resident Macrophages during Group 3 Innate Lymphoid Cell-Driven Colitis." Immunity 49(2): 342-352 e345
in vivo macrophage depletion	Gordon, S. R., et al. (2017). “PD-1 expression by tumour-associated macrophages inhibits phagocytosis and tumour immunity." Nature 545(7655): 495-499
in vivo macrophage depletion	Moynihan, K. D., et al. (2016). “Eradication of large established tumors in mice by combination immunotherapy that engages innate and adaptive immune responses." Nat Med. doi: 10.1038/nm.4200
in vivo macrophage depletion	Arnold, I. C., et al. (2015). “CD11c monocyte/macrophages promote chronic Helicobacter hepaticus-induced intestinal inflammation through the production of IL-23." Mucosal Immunol. doi: 10.1038/mi.2015.65
in vivo macrophage depletion	Kaminsky, L. W., et al. (2015). “Redundant Function of Plasmacytoid and Conventional Dendritic Cells Is Required To Survive a Natural Virus Infection." J Virol 89(19): 9974-9985
in vivo monocyte depletion	Naik, S., et al. (2015). “Commensal-dendritic-cell interaction specifies a unique protective skin immune signature." Nature 520(7545): 104-108
in vitro CSF-R1 neutralization	Sheng, K. C., et al. (2014). “IL-3 and CSF-1 interact to promote generation of CD11c+ IL-10-producing macrophages." PLoS One 9(4): e95208.
in vivo monocyte depletion	Greter, M., et al. (2012). “GM-CSF controls nonlymphoid tissue dendritic cell homeostasis but is dispensable for the differentiation of inflammatory dendritic cells." Immunity 36(6): 1031-1046.
in vivo macrophage depletion	Tagliani, E., et al. (2011). “Coordinate regulation of tissue macrophage and dendritic cell population dynamics by CSF-1." J Exp Med 208(9): 1901-1916
in vivo macrophage depletion	Lim, A. K., et al. (2009). “Antibody blockade of c-fms suppresses the progression of inflammation and injury in early diabetic nephropathy in obese db/db mice." Diabetologia 52(8): 1669-1679.