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Innovative Research of America(IRA)—藥物定量定時緩釋系統(tǒng)

Innovative Research of America(IRA) 是一家致力研發(fā)于藥物定量定時緩釋系統(tǒng)的專業(yè)化公司，又稱Matrix-Driven Delivery (MDD) 給藥系統(tǒng)。該給藥系統(tǒng)由一個可生物吸收的基質(zhì)組成，含有定量可控的活性給藥成分，可以以設(shè)定的劑量在一定時間范圍內(nèi)進(jìn)行給藥。

給藥天數(shù)及劑量的選擇：依據(jù)研究人員實(shí)驗(yàn)需要確定，如某實(shí)驗(yàn)需要在3周內(nèi)給大鼠皮下給某種藥x mg，首先在本公司產(chǎn)品目錄中選取該種藥物，然后選取21天緩釋時間，劑量選擇可以如下方式進(jìn)行：21天共給藥量或每天給藥量，計(jì)算出總的藥物劑量。本公司常規(guī)的給藥時間有21，,60，90天，即可選擇21天的給藥時間（如常規(guī)給藥時間不滿足實(shí)驗(yàn)設(shè)計(jì)，可公司進(jìn)行產(chǎn)品定制）。同樣，給如本公司提供的常規(guī)給藥劑量不滿足實(shí)驗(yàn)設(shè)計(jì)，也可公司進(jìn)行產(chǎn)品定制。本公司可根據(jù)客戶需要在給藥系統(tǒng)中加入可在規(guī)定期間釋放一定劑量的活性藥物。

給藥方法：皮下（一般選取背部或頸部皮膚松弛部位）植入本給藥系統(tǒng)。手工植入方法為選取植入部位，切開一個藥丸直徑相當(dāng)?shù)那锌冢詿o菌鑷子自切口探入，深入皮下至2cm處，用鑷子將藥丸送入離切口2cm處，縫合切口即可。切忌：（1）切口及鑷子探入時傷及肌肉層，可引起炎癥，影響藥物釋放及實(shí)驗(yàn)；（2）鑷子送入藥丸時切勿破壞藥丸，否則影響藥丸緩釋效應(yīng)，影響實(shí)驗(yàn)結(jié)果。

使用套針給藥（另售）：將藥丸放入給藥套針，選取給藥點(diǎn)，扎入針頭，在不傷及肌肉的情況下將針深入扎入處2cm，將藥丸推入皮下，抽出套針即可，無需縫合。

相關(guān)參考文獻(xiàn)：

1. BARAZZONE-ARGIROFFO, MUZZIN, DONATI, KAN, AUBERT, PIGUET. AMERICAN JOURNAL OF PHYSIOLOGY: LUNG, CELLULAR AND MOLECULAR PHYSIOLOGY, 281 (5) : pp.L1150-L1156, 2001.Product.NADOLOL - Dosage 0.5 MG - Release Time 21-DAY - Pellet Type: Stock

2. GARCIA, DEBINSKI, GUTKOWSKA, KUCHEL, THIBAULT, GENEST, CANTIN. BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 131 (2) : pp.806-814, 1985. Product. DEOXYCORTICOSTERONE ACETATE (DOCA) - Dosage 25MG - Release Time 21-DAY - Pellet Type: Stock.

3. DAMASSA, GUSTAFSON, KWIECINSKI, PRATT. BIOLOGY OF REPRODUCTION, 33 (5) : pp.1138-1146, 1985. Product. D-THYROXINE - Dosage 0.5MG - Release Time 21-DAY - Pellet Type: Stock.

4. WASHBURN, KRANTZ, AVERY, REEDLAND.FASEB ABSTRACT FORM 535-5, 1990. 17ß-ESTRADIOL - Release Time 21-DAY - Pellet Type: Stock.

5. TOKARZ. HORMONES AND BEHAVIOR, 21 (3) : pp.358-370, 1987. Product. CORTICOSTERONE - Dosage 0.1MG - Release Time 21-DAY - Pellet Type: Stock

6. REES, PANESAR, STEINER, FLEMING. HORMONES AND BEHAVIOR, 46 (4) : pp.411-419, 2004. Product. CORTICOSTERONE - Dosage 75MG - Release Time 21-DAY - Pellet Type: Stock

7. GORDON, SHELNESS, NICOSIA, WILLIAMS. JOURNAL OF BIOLOGICAL CHEMISTRY, 263 (6) : pp.2625-2631, 1988. Product. 17ß-ESTRADIOL - Dosage 100MG - Release Time 21-DAY - Pellet Type: Stock.

8. CONNOR, SAWCZUK, BENSON, TOMASHEFSKY, O'TOOLE, OLSSON, BUTTYAN. PROSTATE, 13 (2) : pp.119-130, 1988. Product. VERAPAMIL - Dosage 100MG - Release Time 21-DAY - Pellet Type: Stock

9. MOR, ZAINO, SATYASWAROOP. AMERICAN JOURNAL OF OBSTETRICS AND GYNECOLOGY, 162 (4) : pp.928-936, 1990. Product. 17ß-ESTRADIOL - Dosage 200 PG/ML - Release Time 60-DAY - Pellet Type: Stock.

10. SATYASWAROOP, ZAINO, MOR. CANCER AND MATASTISIS REVIEWS, 6 : pp.223-241, 1987. Product. 17ß-ESTRADIOL - Dosage N/A - Release Time 60-DAY - Pellet Type: Stock

11. WANG, NAN, YU, AGRAWAL, ZHANG. CLINICAL CANCER RESEARCH , 7 (11) : pp.3613-3624, 2001. Product. 17ß-ESTRADIOL - Dosage 1.7MG - Release Time 60-DAY - Pellet Type: Stock

12 .BIANCO, STRIZZI, EBERT, CHANG, REHMAN, NORMANNO, GUEDEZ, SALLOUM, GINSBURG, SUN, KHAN, HIROTA, WALLACE-JONES, WECHSELBERGER, VONDERHAAR, TOSATO, STETLER-STEVENSON, SANICOLA, SALOMON. JOURNAL OF THE NATIONAL CANCER INSTITUTE, 97 (2) : pp.132-141, 2005. Product .17ß-ESTRADIOL - Dosage 0.72 MG - Release Time 60-day - Pellet Type: Stock.

13. ZAINO, SATYASWAROOP, MOR. SCIENCE, 219 (4580) : pp.58-60, 1983. Product. 17ß-ESTRADIOL - Release Time 60-DAY - Pellet Type: Stock

14. ENGELSON, PI-SUNYER, KOTLER. NUTRITION, 15 (6) : pp.465-473, 1999. Product. MEGESTROL ACETATE - Dosage 50 MG - Release Time 90-DAY - Pellet Type: Stock and TESTOSTERONE PROPIONATE - Dosage 35 MG - Release Time 90-DAY - Pellet Type: Stock.