TENOVIN-1  380315-80-0

Tenovin-1
分子式：C20H23N3O2S   分子量：369.48
 
產品描述
Tenovin-1防止MDM2介導的p53的降解，涉及泛素化途徑，通過抑制SirT1和SirT2的蛋白脫乙酰活性。
靶點
p53
         
IC50
           
體外研究
Tenovin-1 is a p53 activator and elevates the amount of p53 protein within 2 hr of treatment. Tenovin-1 treatment does not alter p53 mRNA levels. Tenovin-1 (10μM) protects p53 from mdm2-mediated degradation with little effect on p53 synthesis. Tenovin-1 represses cell growth, and induces apoptosis in a panel of tumor cells expressing p53. Tenovin-1 acts through inhibition of the protein-deacetylating activities of SirT1 and SirT2, two important members of the sirtuin family.
體內研究
Initial in vivo experiments indicated that tenovin-1 impairs the growth of BL2-derived tumor xenografts.
溶解性
DMSO 0.25 mg/ml
穩定性
2年 -20°C粉狀，6月-80°C溶于DMSO